Quick note: SGKB and PDB tutorials

19 March, 2010 (12:24) | Genomics Resource News | By: Trey

We recently announced a free tutorial (sponsored by PSI) on the Structural Genomics Knowledgebase (SGKB). I thought it might be of interest to our readers. You can access the free tutorial (approx. a 1hr movie, slides, handouts and exercises) here.

We will also soon announce a free tutorial on the Protein Database (PDB), but you can already access it here.

For a full list of our free tutorials and training materials, click here (about a dozen), or view our other 80 or more tutorials on a wide range of topics by subscription.

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Update on Biocuration 2010 Meeting

19 March, 2010 (08:10) | Uncategorized | By: Jennifer

I got an email from Tadashi Imanishi about the upcoming Biocuration meeting occurring in Japan and I wanted to pass the news on. The conference details have changed slightly in that it will be occurring October 11th-14th in Tokyo, rather than Oct. 6-9th in Chiba:

The new dates and place for the Biocuration 2010 meeting will be as follows:
==========
Date: October 11(Mon)-14(Thu), 2010
Place: Plaza HEISEI
-Address: 2-2-1 Aomi, Koto-ku, Tokyo 135-8630, Japan
-HP: http://www.tiec.jasso.go.jp/plaza/index_e.html
-Map: http://www.tiec.jasso.go.jp/info/map_e.html
==========
#Some sessions may be held in other meeting rooms in nearby buildings.

I personally am very excited about the change – Chiba looked absolutely beautiful, but I can’t imagine a greater thrill than getting to experience Tokyo as a guest of colleagues from Tokyo! I have never been to Japan before, but have seen it featured on the travel channel many times – I’m usually ready to pack my bags before the end of the program. And attending the conference in a venue so close to the National Institute of Advanced Industrial Science and Technology (AIST) is just very cool. I’ve heard of so many cutting-edge experiments in curation from Japanese biocurators at past conferences & OpenHelix has so much respect for foundational scientific resources such as KEGG and H-InvDB, and others – well, getting to go there and learn sounds like an unimaginably cool opportunity.

Last year I was selected to give a talk at the Third International Biocuration Conference in Berlin. Since Berlin was on my husband’s ’short list’ of places he’d like to visit, he came along too & we had a wonderful time with the city and the science. Well, guess what other city is on his short list – yep, Tokyo. I don’t know if we will be able to send everyone at OpenHelix who would like to attend this conference, but fingers crossed that I’ll be seeing you in Tokyo in October! :)

Stay tuned here for more details, and I’m sure information will be posted at the International Society for Biocuration (ISB) conference listing soon.  

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What’s your problem? Open Thread

18 March, 2010 (07:39) | What's Your Problem? | By: Mary

wyp_q_mark2_thumbnail1Welcome to the “What’s Your Problem?” (WYP) open thread. The purpose of this entry is to allow the community to ask questions on the use of genomics resources. Think of us as a virtual help desk. If you have a question about how to access a certain kind of data, or how to use a database, or what kind of resources there are for your particular research problem, just ask in the comments. OpenHelix staff will keep watch on the comment threads and answer those questions to the best of our knowledge. Additionally, we encourage readers to answer questions in the comments too. If you know the answer to another reader’s question, please chime in! The “WYP” thread will be posted every Thursday and remain at the top of the blog for 24 hours. Questions or problems asked on Thursday will be answered on Thursday to the best of our ability. You can leave questions on other days of the week, but the answer might not come that day.

We’d also like to invite resource providers to let us know if they have something new to talk about, or something they want to mention to the bioinformatics community. We’ve had some people email us because they weren’t sure if they should post something, and we want to say that’s fine.

So What’s Your Problem? And What’s Your Solution? :)

You can keep up with this thread by remembering to check back, by subscribing to the RSS comments feed to this WYP post or by subscribing to be notified by email of new comments to the post (use checkbox at end of comment form, you can unsubscribe later). If you want to be notified of future WYP posts (every Thursday), you can subscribe to the WYP feed.

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Computational biologists: “They’re going to be the breakthrough artists.”

18 March, 2010 (08:05) | Genomics Research | By: Mary

So my Tivo picked up the Charlie Rose interview with Francis Collins the other day.  I wasn’t sure if I wanted to watch it, since it was being pitched as a book tour stop for the new “belief” book by Collins.  But I decided to wade in nonetheless.  As it turns out, Francis separated himself from the book shilling very clearly in the end.  And there were some enjoyable parts in the earlier portion of the interview.  My favorite excerpts were about computational biologists:

CHARLIE ROSE: You have said if you were starting over you would be a computational biologists.


FRANCIS COLLINS: I did say that. I still say that. Computational biologists
are having a really good time and it’s going to get better.

CHARLIE ROSE: Their day is coming?

FRANCIS COLLINS: Their day is here, but it’s going to be even more here in a few years.

So what do they do? They are people who are jointly trained in studying biology in all of its complexes, but they’re also very capable at computation analysis of huge data sets, because — in part because of NIH and the ethic that was adopted by the genome project, huge amounts of data are being made publicly accessible everyday about all kinds of disease questions.

CHARLIE ROSE: So they’re going to be the break through artists of the future?

FRANCIS COLLINS: They’re going to be the breakthrough artists….

So, team computational biology–ever been called a breakthrough artist? I liked the sound of that. Our day is here, baby. Let’s get crackin’.

It was funny, when I first started watching I thought to myself: huh, he’s lost weight.  And during the course of the interview he also discusses the changes he’s made to his diet and exercise routine since finding out his diabetes risk via personal genomics.

I can’t figure out how to embed these now–used to be able to.  You’ll have to go over to the Charlie Rose site if you want to watch. http://www.charlierose.com/view/interview/10909

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Tip of the Week: Word Add-In for Ontology Recognition

17 March, 2010 (08:07) | Tip of the Week | By: Jennifer

In today’s tip I want to make you aware of a tool that I think will help researchers to present their own data and publications in an accurate and universally searchable way. I learned of the resource (UCSDBioLit) through an article in one of my recent BioMed Central article alert emails. This resource allows authors to mark-up their own publications with XML tags AS THEY WRITE their papers. This will allow faster and more accurate semantic searching of their research.

A huge problem in science today is the ability to quickly search the vast literature base and to accurately and efficiently find the data that you are interested in. Here at OpenHelix we focus on ways of effectively and efficiently get information out of public databases and resources, but at the other end of the process is the ability for scientific knowledge to be curated into those resources. We have featured biocurators and the phenomenal work that they do several times in the past, but it is work that never ends and can be very labor intensive. It often involves an initial triaging of a field’s literature, some level of automatic information gathering, and then careful manual effort on the part of scientist at the resource to gather and present the information through their site. I know from personal experience that the process of reading a paper, clarifying research details with an author, and then presenting that information to the author’s satisfaction can be a very long & labor intensive process, for both the curator AND the original author.

For years there has been discussion of ‘expert curation’ in which experts in the field author review or summary pages in a resource, or community curation jamborees, etc. And there have been fruits from many of these efforts, but in general participation is low. But who is more of an expert on the research being published other than the author himself? If authors could/would mark up their own papers during the publication process, not only could they be assured that it would be accurate but they would help make their research universally searchable without the lag required for searchability through a specific resource. Thus far document mark-up is has not been an easy process and has largely been deemed ‘not worth the effort’ for the level of attribution/recognition affiliated with it.

The BioMed Central article does a nice job of outlining and discussing many of these issues. It cites many other efforts and resources, explains their motivation and the implementation of their software. A nice feature of the tool is that there are interoperability features, and a real commitment to conforming with existing standards of practice. The article also presents an appendix of resource addresses of other groups involved in semantic searching and literature publication. I especially like this quote from the paper:

The Word add-in presented here will assist authors in this effort using community standards and by making it possible for the author of the document, the absolute expert on the content, to do so during the authoring process and to provide this information in the original source document.

You can also find brief tutorials on using the tool at SciVee: Word Add-in for Ontology Recognition Tutorial (1 of 4): Install Process

As a note, literature mark-up and enabling are currently an active area – Mary found another literature handling resource and paper as well: Check out the tip, the articles & the tools. Tell me what you find/think. Thanks! (OH, and Happy St. Patty’s to ya!)

UCSDBioLit Reference:
ResearchBlogging.org
Fink, J., Fernicola, P., Chandran, R., Parastatidis, S., Wade, A., Naim, O., Quinn, G., & Bourne, P. (2010). Word add-in for ontology recognition: semantic enrichment of scientific literature BMC Bioinformatics, 11 (1) DOI: 10.1186/1471-2105-11-103

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Another day, another genome: Hydra

16 March, 2010 (08:09) | Genomics Research | By: Mary

Ok, I had no idea hydra was even in the pipeline.  I’m a fan of hyda from the days way back in the developmental biology lab.  We were assaulting hydra in various ways and watching the regeneration ensue.  It was very compelling to see how they reacted to removed tentacles, split body axes, and such.

So when I saw the news about this paper in Nature I went over for a look: The dynamic genome of Hydra is an early look at the genome–the assembly isn’t complete.  But it still has some useful tidbits.  About 20,000 genes at this point, some are clearly in known pathways such as Hox members and Wnt signalling genes.

The best chuckle I got out of the paper, though, is the transposable elements.  I still haven’t recovered from the corn TEs (which make up more than 80% of corn), and here we go again.

Transposable elements make up ~57% of the Hydra genome and represent over 500 different families….

I’m beginning to think that all of this biology stuff is just a way to disperse transposable elements.  Who knew?

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FYI: NCBI Has Officially Announced New dbVar Resource

15 March, 2010 (15:55) | Genomics News, Genomics Resource News, New Resource | By: Jennifer

As I was browsing over NCBI’s homepage, I happened to notice an announcement dated March 2nd that stated that the dbVar resource that Mary mentioned briefly in a weekly tip a while back is now publicly available. Here’s the brief announcement:

Tuesday, March 02, 2010, 1:00:00 PM
NCBI’s new database of Genomic Structural Variation (dbVar) archives large scale genomic variation data as well as associations of defined variants with phenotypic information.

You can find this announcement and others here.

From the dbVar documentation, it looks like it is mostly in ‘collection mode’ at the moment with lots and lots of data being added, FAQs on how to submit to dbVar, and some background information on what structural variation is, and how it is detected. It looks like the actual graphical displays of the variations use NCBI’s Sequence Viewer. It will be interesting to see how this new NCBI resource grows and is utilized.

edit: 3/16 9am – links to dbVar all appear to be down today. We have an email in to NCBI & will keep you posted on anything that we hear from them.

edit 2: 3/16 1pm – The links to dbVar are working for me now. Thanks, NCBI, for the quick fix!

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Genetic Dieting

12 March, 2010 (16:09) | General Science, Genomics News | By: Trey

Just some light Friday reading. I’ve seen ads and articles about “body type diets” and diets supposedly based on our genetics, “Genotype Diet.”  It has interested me. I gained 80lbs over the last 10 years and spend most of that time trying different methods (low carb, etc, etc) to lose that. Finally lost 60 using that old-fashioned way, Weight Watchers :D . And though I’m sure there are differences in how we individually eat, crave and put on/take off weight based on our genotypes, I’ve never seen solid scientific evidence that we can determine what those genotypes are in such a way that we can figure out the ‘best’ diet for each of us. Frankly, I’ve come to the conclusion the “best” diet for all of is to each whole fresh food, less of it and lots of plants (where have I read that?), so I tend to believe the complication of trying to figure out what our ‘genotype diet’ might be is wasted effort for the most part (except when it comes to things like gluten intolerance, etc. of course) and that most of these ‘diets’ are, to put it in scientific terms, hokum.

Yet, a new study was just published that suggests that our genes do indeed (as our anecdotal experiences suggest) have an effect on how we respond to different ways of eating. Yet, the study is a small sample (58 women) and there are some other caveats (like the sponsor of the study does a genetic test to determine the best diet :/), but it does look interesting: Genetically Determined Dieting? Maybe Not Yet – Shots – Health News Blog : NPR.

I’ll wait till more extensive, conclusive study comes out to say what effects our genes have on what diet we respond to best, but frankly, most of us would probably do pretty well eating a mainly a lot of of whole fruit, vegetables, nuts, legumes and grains with a bit of lean meat and dairy (if we are so inclined). Very simple (not easy, but quite simple).

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What’s your problem? Open Thread

11 March, 2010 (08:14) | What's Your Problem? | By: Mary

wyp_q_mark2_thumbnail1Welcome to the “What’s Your Problem?” (WYP) open thread. The purpose of this entry is to allow the community to ask questions on the use of genomics resources. Think of us as a virtual help desk. If you have a question about how to access a certain kind of data, or how to use a database, or what kind of resources there are for your particular research problem, just ask in the comments. OpenHelix staff will keep watch on the comment threads and answer those questions to the best of our knowledge. Additionally, we encourage readers to answer questions in the comments too. If you know the answer to another reader’s question, please chime in! The “WYP” thread will be posted every Thursday and remain at the top of the blog for 24 hours. Questions or problems asked on Thursday will be answered on Thursday to the best of our ability. You can leave questions on other days of the week, but the answer might not come that day.

We’d also like to invite resource providers to let us know if they have something new to talk about, or something they want to mention to the bioinformatics community. We’ve had some people email us because they weren’t sure if they should post something, and we want to say that’s fine.

So What’s Your Problem? And What’s Your Solution? :)

You can keep up with this thread by remembering to check back, by subscribing to the RSS comments feed to this WYP post or by subscribing to be notified by email of new comments to the post (use checkbox at end of comment form, you can unsubscribe later). If you want to be notified of future WYP posts (every Thursday), you can subscribe to the WYP feed.

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Come to the carnival….

11 March, 2010 (08:35) | Genomics Resource News | By: Mary

There’s a new carnival in town.  It was all the buzz on the #bioinformatics twitter feed the last couple of days.  Byte Size Biology delivers the first edition of:

Bioinformatics Blog Carnival #1

For those of you who aren’t as immersed in science blogginess as others, a carnival is a collection of blog posts usually around a given theme or goal.  They are nice–they generate networks in the community, and you might find blogs and bloggers that you wouldn’t have been aware of otherwise.  In this case there is quite a range of topics, maybe there will be something you’ll connect with.  Go check it out!

Bioinformatics Blog Carnival #1

I would have submitted something if I had heard about it in time, but I was away. Alas. There’s always next time. But I can’t fingure out when next time is yet…

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